The Dyer County Sheriff's Office Patrol Division is tasked with patrolling over total area of 526 square miles of which 510 square miles is land  and 16 square miles of waterways.

Dyer County is bisected by U.S. Route 51, a major highway connecting Memphis with Chicago from south to north.

To the west, Dyer County is connected to Missouri by Interstate 155 over the Mississippi River which borders the state of Arkansas.

These entities make Dyer County a throughfare for criminal activity which are suppressed by a proactive Dyer County Sheriff's Patrol Division.